This talk presents the MYRTUS Design and Programming Environment (DPE), an interoperable framework for modeling and deploying applications across the computing continuum. The environment features an MLIR-based infrastructure to support diverse hardware targets while allowing the seamless import of third-party code. We report on current support for FPGA and CGRA targets. A key aspect of the DPE is to support adaptability in the computing continuum by exploring operating points at design time, enabling a runtime engine to dynamically adapt configurations for energy efficiency. Additionally, the talk covers reactive programming, including enclaves and quasi-static scheduling to bridge the gap between high-level models and low-level executable schedules, ensuring efficient and deterministic execution in the context of cyber-physical systems.